World Market for Anti-Infectives (Antifungals, Antibacterials and Antivirals)

This Kalorama Information report - The World Market for Anti-Infectives - focuses on three key segments of treatment:

• Antifungals (Allylamines, Azoles, Polyene Macrolides, Other Antifungals)
• Antibacterials (Aminoglycosides, Carbapenems, Cephalosporins, Macrolides, Penicillins, Quinolones, Sulfonamides, Tetracyclines, Others)
• Antivirals (Nucleoside Analogs, Transcriptase Inhibitors, DNA Polymerase Inhibitors, Protease Inhibitors, Other Antivirals)

The report covers both currently marketed and late stage development products. Revenues for each segment were generated using dollar and unit sales for each product.

A novel approach in this report is that it provides revenue by product type but also the 'market' for treatments by type of infection, enabling marketers to research the best markets where a variety of products may be implemented.

The report includes statistical information for infections by type worldwide, with special emphasis on the U.S. and Europe. The market segments provide an overview, description of products on the market, description of products in development, market estimates and forecasts, and competitive analysis of leading providers.

The area of anti-infectives represents an exciting frontier for development of potential life-saving products. However, there are a number of issues and trends that have a direct influence on this market and manufacturers' ability to successfully operate in the market. The issues and trends affecting this market include:

• Drug Resistance
• HIV Trends, Cost, and Access to Drug Therapy
• Other Immunocompromised Population Issues
• Alliances and Partnerships
• New Developments
• Rx-to-OTC Switches

All market data pertains to the world market at the manufacturers' level. The base year for data was 2011. Historical data was provided for the years 2007 through 2010, with forecast data provided for 2012 through 2015. Compound annual growth rates (CAGRs) are provided for the 2007-2011, 2011-2015 and 2007-2015 periods for each industry segment covered. Competitive analysis is provided for the years 2007 through 2011 with a special focus on 2011. The forecasted market analysis for 2011-2015 was based on probability of approval and sales of products in late stage development, future trends in current product demand, generic penetration, product marketing, and relevant demographic trends.

Companies profiled in this report include:

• Abbott Laboratories
• Astellas
• AstraZeneca
• Bayer
• Bristol-Myers Squibb
• Cubist
• Daiichi Sankyo
• Gilead Sciences
• GlaxoSmithKline
• Johnson & Johnson
• Merck
• Novartis
• Pfizer
• Roche

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY
Introduction
Scope and Methodology
Total Size and Growth of the Market
Issues and Trends Affecting Market
Leading Competitors

CHAPTER TWO: INTRODUCTION AND INDUSTRY TRENDS
Overview
Introduction to Pathogens
Demographics of the World
Life Expectancy
Infections and Drug Resistance
Causes of Drug Resistance
Drug Resistance in Select Populations
Measures for Reducing Resistance
HIV Trends
Manufacturer and Marketer Trends
Trends in Partnerships and Alliances
Developers Trends
Aradigm
ARD-3100
Phase II
Cystic fibrosis
ARD-3150
Phase II
Bronchiectasis
ARD-1100
Preclinical
Inhalation anthrax
Trends in Rx-to-OTC Switches

CHAPTER THREE: ANTIFUNGAL DRUGS
Overview
Types of Fungal Infections
Superficial
Systemic
General Fungal Infection Statistics
Fungal Infection Risk
Description of Antifungal Products
Systemic Antifungals
Topical Antifungals
Market Overview
Total Market Size and Forecast
Antifungal Market by Product Type
Antifungal Market by Geographical Region
Market Analysis by Treated Condition
Competitive Analysis
Leading Products

CHAPTER FOUR: ANTIBACTERIAL DRUGS
Overview
Classification of Antibacterial Organisms
Antimicrobial Spectrum
Bacterial Resistance
Principles of Anti-bacterial Therapy
Combination Therapy and Prophylactic Use
Bacterial Infection Statistics
Bacterial Infection Risk
Classifications of Antibacterial Products
Aminoglycosides
Carbapenems
Cephalosporins
Macrolides
Penicillins
Quinolones
Sulfonamides
Tetracyclines
Market Overview
Total Market Size and Forecast
Antibacterial Market by Product Type
Antibacterial Market by Geographical Region
Market Analysis by Treated Condition
Competitive Analysis
Leading Products

CHAPTER FIVE: ANTIVIRAL DRUGS
Overview: Introduction to Viruses
Examples of Pathogenic Viruses
Virus Function and Life History
Replication in DNA Viruses
Replication of RNA Viruses
Replication in Retroviruses
Host Defenses Against Viruses 8
Viral Ploys to Invade Host Cells and Circumvent Host Responses
Invasion of Host Cells
Subversion of the Immune Response
Avoidance of Immune Detection and Attack by Killer Cells
HIV and AIDS
Viral Infection Statistics
Description of Antivirals Products
Nucleoside Analogs, Transcriptase Inhibitors and DNA Polymerase Inhibitors
Protease Inhibitors
Other Antivirals
Market Overview
Total Market Size and Forecast
Antiviral Market by Product Type
Antiviral Market by Geographical Region
Market Analysis by Treated Condition
Competitive Analysis
Leading Products

CHAPTER SIX: MARKET SUMMARY
Market by Product Segment (Antifungals, Antibacterials, Antivirals)

CHAPTER SEVEN: CORPORATE PROFILES
Introduction
Abbott Laboratories
Astellas
AstraZeneca
Bayer Healthcare Pharmaceuticals (Bayer Schering Pharma)
Bristol-Myers Squibb
Cubist
Daiichi Sankyo
Gilead Sciences
GlaxoSmithKline
Johnson & Johnson
Merck
Novartis
Pfizer
Roche

APPENDIX: COMPANY DIRECTORY

CHAPTER ONE: EXECUTIVE SUMMARY
Table 1-1: The Global Market for Anti-Infectives by Product Segment, 2007-2015
Figure 1-1: The Global Market for Anti-Infectives by Product Segment, 2011
Figure 1-2: World Market for Anti-Infectives Estimated Market Share of Leading Suppliers, 2011
CHAPTER TWO: INTRODUCTION AND INDUSTRY TRENDS
Table 2-1: World Population by Selected Geographical Region, 2010 - 2050
Table 2-2: Average Life Expectancy in Years by Country 1980, 2004 and 2009
Figure 2-2: Average Life Expectancy in Years by Country 1980 and 2009
Table 2-3: Worldwide HIV/AIDS Infections
Table 2-4: Women Living with HIV/AIDS, by Region 2001 to 2009, Number
Table 2-5: Antiretroviral Access for HIV Infected Individuals in Low- and Middle-Income Countries, 2009 based on 2010 WHO Guidelines
Table 2-6: Antiretroviral Access for HIV Infected Individuals in Low- and Middle-Income Countries, by Selected Countries, 2009 based on 2010 WHO Guidelines
Table 2-7: Anti-Infective Drugs in Development by Developer
Table 2-8: Anti-infectives Ingredients Transferred from Rx-to-OTC Status
Figure 2-3: Anti-infectives Ingredients Transferred from Rx-to-OTC by Year
CHAPTER THREE: ANTIFUNGAL DRUGS
Table 3-1: Incidence of Infections by Type, 2010
Figure 3-1: Incidence of Infections by Type, 2010
Table 3-2: World Population at Risk for Fungal Infections, Secondary to Chronic Diseases by Selected Geographical Region, 2010
Figure 3-2: World Population at Risk for Fungal Infections, Secondary to Chronic Diseases by Selected Geographical Region, 2010
Table 3-3: Treatment Options for Fungal Infections , (Type, Brand, and Manufacturer)
Table 3-4: The World Market for Antifungal Drugs 2007-2015
Figure 3-3: The World Market for Antifungal Drugs 2007-2015
Table 3-5: Antifungal Drug Market by Type 2007-2015 , (Allylamines, Azoles, Polyene Macrolides, Other Antifungals)
Figure 3-4: The World Market for Antifungal Drugs Revenues by Type 2007-2015 , (Allylamines,    Azoles, Polyene Macrolides, Other Antifungals)
Figure 3-5: The World Market for Antifungal Drugs Revenues by Type 2011 and 2015 , (Allylamines, Azoles, Polyene Macrolides, Other Antifungals)
Table 3-6: The World Market for Antifungal Drugs Estimated Products Sales by Geographic Region 2007-2015
Figure 3-6: The World Market for Antifungal Drugs Estimated Product Sales by Geographic Region 2007-2015
Table 3-7: World Antifungal Market Estimated Products Sales by Infection Type , (Candida Infections, Seborrheic Dermatitis, Onychomycosis, Other Infections)
Figure 3-7: World Antifungal Market Estimated Distribution of Products Sales by Infection Type, 2011 Candida Infections, Seborrheic Dermatitis, Onychomycosis, Other Infections)
Table 3-8: World Market for Antifungal Drugs Estimated Revenues and Market Share of Leading Suppliers 2007-2011
Figure 3-8: World Market for Antifungal Drugs Estimated Revenues of Leading Suppliers, 5-year Comparison 2007-2011
Figure 3-9: World Market for Antifungal Drugs Estimated Market Share of Leading Suppliers, 2011
Table 3-9: World Market for Antifungal Drugs Estimated Sales of Select Products 2007-2011
Figure 3-10: World Market for Antifungal Drugs Estimated Sales of Select Products 2007-2011
CHAPTER FOUR: ANTIBACTERIAL DRUGS
Table 4-1: Antibiotics with Difficult Penetration
Table 4-2: Estimated World and U.S. Incidence of Bacterial Infections, 2010
Figure 4-1: Estimated World and U.S. Incidence of Bacterial Infections
Table 4-3: World Population at Risk for Serious Bacterial Infections, Secondary to Chronic Diseases by Selected Geographical Region, 2010
Figure 4-2: World Population at Risk for Serious Bacterial Infections, Secondary to Chronic Diseases by Selected Geographical Region, 2010
Table 4-4: Treatment Options for Bacterial Infections , (Type, Brand, and Manufacturer)
Table 4-5: The World Market for Antibacterial Drugs 2007-2015
Figure 4-3: The World Market for Antibacterial Drugs 2007-2015
Table 4-6: Antibacterial Drug Market by Type 2007-2015
Figure 4-4: The World Market for Antibacterial Drugs Revenues by Type, 2007-2015 , (Aminoglycosides, Carbapenems, Cephalosporins, Macrolides, Penicillins, Quinolones, Sulfonamides, Tetracyclines, Others)
Figure 4-5: The World Market for Antibacterial Drugs Revenues by Type 2011 and 2015 , (Aminoglycosides, Carbapenems, Cephalosporins, Macrolides, Penicillins, Quinolones, Sulfonamides, Tetracyclines, Others)
Table 4-7: The World Market for Antibacterial Drugs Estimated Products Sales by Geographic Region 2007-2015
Figure 4-6: The World Market for Antibacterial Drugs Estimated Product Sales by Geographic Region 2007-2015
Table 4-8: World Antibacterial Market Estimated Products Sales by Infection Type , (Upper and Lower Respiratory Tract Infections, Ear, Sinus Infections, Skin & Skin Structure Infections Gynecological Infections; Sexually Transmitted Infections, Urinary Tract Infections, Abdominal Infections, Other Infections)
Figure 4-7: World Antibacterial Market Estimated Distribution of Products Sales by Infection Type, 2011    , (Upper and Lower Respiratory Tract Infections, Ear, Sinus Infections, Skin & Skin Structure Infections Gynecological Infections; Sexually Transmitted Infections, Urinary Tract Infections, Abdominal Infections, Other Infections)
Table 4-9: World Market for Antibacterial Drugs Estimated Revenues and Market Share of Leading Suppliers 2007-2011
Figure 4-8: World Market for Antibacterial Drugs Estimated Revenues of Leading Suppliers 2007-2011
Figure 4-9: World Market for Antibacterial Drugs Estimated Market Share of Leading Suppliers, 2011
Table 4-10: World Market for Antibacterial Drugs Estimated Sales of Select Products 2007-2011
CHAPTER FIVE: ANTIVIRAL DRUGS
Table 5-1: Host Cell Receptors
Table 5-2: Estimated World and U.S. Incidence of Viral Infections, 2010
Figure 5-1: Estimated World and U.S. Incidence of Leading Viral Infections
Table 5-3: Treatment Options for Viral Infections , (Type, Brand, and Manufacturer)
Table 5-4: The World Market for Antiviral Drugs 2007-2015
Figure 5-2: The World Market for Antiviral Drugs 2007-2015
Table 5-5: Antiviral Drug Market by Type 2007-2015
Figure 5-3: The World Market for Antiviral Drugs Revenues by Type , (Nucleoside Analogs, Transcriptase Inhibitors, DNA Polymerase Inhibitors, Protease Inhibitors, Other Antivirals) 2007-2015
Figure 5-4: The World Market for Antiviral Drugs Revenues by Type , (Nucleoside Analogs, Transcriptase Inhibitors, DNA Polymerase Inhibitors, Protease Inhibitors, Other Antivirals) 2011 and 2015
Table 5-6: The World Market for Antiviral Drugs Estimated Products Sales by Geographic Region 2007-2015
Figure 5-5: The World Market for Antiviral Drugs Estimated Product Sales by Geographic Region 2007-2015
Table 5-7: World Antiviral Market Estimated Products Sales by Infection Type (HIV, Hepatitis, Other Infections, Total)
Figure 5-6: World Antiviral Market Estimated Distribution of Products Sales by Infection Type, 2011    (HIV, Hepatitis, Other Infections, Total)
Table 5-8: World Market for Antiviral Drugs Estimated Revenues and Market Share of Leading Suppliers 2006-2009
Figure 5-7: World Market for Antiviral Drugs Estimated Revenues of Leading Suppliers 2007-2011
Figure 5-8: World Market for Antiviral Drugs Estimated Market Share of Leading Suppliers, 2011
Table 5-9: World Market for Antiviral Drugs Estimated Sales of Top Products 2007-2011
Figure 5-9: World Market for Antiviral Drugs Estimated Sales of Top Products 2007-2011
CHAPTER SIX: MARKET SUMMARY
Table 6-1: The Global Market for Anti-Infectives by Product Segment, 2007-2015
Figure 6-1: The World Market for Anti-Infective Drugs 2007-2015
Figure 6-2: The Global Market for Anti-Infectives by Product Segment, 2011
Figure 6-3: The Global Market for Anti-Infectives by Product Segment, 2015

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